The regulation of adult stem cells contributes to the formation of lung cancer

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Researchers demonstrate a link between the regulation of the growth of adult stem cells and the formation of pre-malignant lesions of the lung that trigger cancer in this region.
Cells composing airway suffer great damage due to exposure to external agents such as snuff, contamination or viral infections.
These damages are repaired by the actions of adult stem cells found in this area. This repair process is controlled by the molecules of the reactive oxygen species (ROS). Recently, described as low levels of ROS are key to the activation of cell division and repair, while high ROS levels are toxic to the stem cells, inducing death.
The study by researchers at the Jonsson Comprehensive Cancer Center have shown how stem cells in airway changes in ROS levels between low and moderate levels are responsible for activating the repair process. Accordingly, once the repair has been initiated, ROS levels are drastically reduced to prevent excessive cell proliferation.
If this natural reduction of ROS levels is compromised, stem cells continue dividing unripe, forming pre-cancerous lesions, eventually may trigger tumor process.
These results are key to the development of new prevention strategies for lung cancer